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Breakthrough ovarian cancer drug offers patients more time and better quality of life

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A breakthrough drug for ovarian cancer that is kinder on the body and extends lives is now available on the NHS.

The drug, called mirvetuximab soravtansine, is a known as a "biological missile" as it delivers chemotherapy drugs direct to the cancerous tissue rather than to the whole body – reducing debilitating side-effects.

Patricia Hill, 64, said the treatment was allowing her to do things – like visiting family and going to the theatre – that were impossible on conventional chemotherapy.

Up to 400 patients a year in England could benefit from the new treatment – the first for hard-to-treat ovarian cancer in 20 years.

There are nearly 7,750 cases of ovarian cancer in the UK each year.

Patricia, from north London, was diagnosed in 2023 and had multiple rounds of chemotherapy. She started on mirvetuximab in January this year.

She said the difference was like night and day, and the therapy had given her "a lot of my life back".

She felt less tired and sick than when treated with standard chemotherapy, so felt "a lot better" and describes the drug as a "bit of a game changer".

The new drug has allowed her to see shows in London's West End, dine out at restaurants, attend the Chelsea Flower Show and visit family in Ireland.

"It actually opens up a lot of possibilities – you can actually go and do a lot more than you would normally do."

The drug – mirvetuximab – extends lives too, from 12.8 months on chemotherapy to 16.5 months on the therapy, on average.

But crucially it improves quality of life. It has fewer side-effects, women are able to keep their hair and it is given by a drip every three weeks, instead of weekly with conventional chemotherapy.

The drug is an advanced form of chemotherapy that hits cancer with a bigger dose, while reducing side-effects.

It is made from a deadly chemotherapy drug that has been fused to an antibody, similar to the ones the body uses to fight infection.

However, these antibodies have been designed to spot markings – called folate receptor alpha – that appear on the outside of some ovarian cancer cells.

So they travel to cancerous cells, stick to the surface and are then absorbed. Once inside they release their toxic payload, to kill the cancer.

This is the reason why this type of therapy is also known as a 'Trojan horse' therapy, after the Greek myth.

About 30-40% of cancers which do not respond to chemotherapy have these markings.

Jenny Green, 71 from Hertfordshire, was diagnosed in 2017 and was part of the clinical trials that proved the drug worked.

She said: "I seem to have tolerated it very well, with hardly any side effects at all. That's been amazing!

"I had a scan that showed my cancer nodules were shrinking, and my bloods were coming back into range – which is all pretty good to hear."

The drug has been approved by the medicines watchdog, the National Institute for Health and Care Excellence (NICE), in ovarian, peritoneal and fallopian tube cancer if chemotherapy no longer works and the cancers have the right markings.

NHS England says it will pay for the drug. Wales and Northern Ireland normally follow the same rules, while Scotland makes its own decisions.

Dr Rowan Miller, who ran the clinical trials at UCLH, said she was "really excited" this drug was coming to the NHS after a 20-year search for better medications.

"Finally, there's a drug that's available, that improves survival for this group of patients and in addition, the patients get on with the treatment well and find it easier to manage than standard chemotherapy," she told me.

Prof Ruth Plummer, NHS national clinical lead for cancer drugs, said it was the "most significant breakthrough" in treating these hard-to-treat ovarian cancers "in over two decades" and added she was "delighted" it was available on the NHS.

Victoria Clare, chief executive officer at Ovacome, the UK's ovarian cancer support charity, said: "This decision has the potential to make a real difference to those who are able to access this treatment. We are delighted."

Mirvetuximab soravtansine has been developed by the pharmaceutical company AbbVie.

Rachel Downing, head of policy and external affairs at Target Ovarian Cancer, said the drug becoming available on the NHS was "a hugely important moment" for women with platinum-resistant ovarian cancer and their families, "who have faced limited effective treatment options for far too long".

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Heat experts warn 'reckless' Fifa of bottle ban health risk

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The 2022 World Cup attracted more than a million fans to Qatar

Fifa has been warned it is putting fans' health at risk by introducing a bottle ban at this summer's World Cup.

Fans will not be allowed to take reusable water bottles into World Cup stadiums due to safety concerns, Fifa said in a late policy change.

The official stadium code of conduct previously stated: "For the avoidance of doubt, empty, transparent, reusable plastic bottles, up to (1 litre in) capacity, may be brought into the stadium."

But seven days before the tournament kicks off on 11 June, bottles – along with cups, jars and cans – have been prohibited, with Fifa saying it will lower the risk of injury caused by fans throwing missiles.

"Fifa is committed to protecting the health and safety of all players, referees, fans, volunteers, and staff," football's world governing body said in a statement.

Fans will be able to buy water in the stadium and Fifa has promised not to charge above their usual venue prices.

But heat experts have criticised the U-turn, with one saying the ban "will clearly heighten the risk of heat-related health incidents".

In May, scientists warned that Fifa's heat safety measures for the tournament are "inadequate", as temperatures at 14 of the 16 host venues are set to exceed dangerous levels.

"Fifa works closely with each host city committee and local authorities on heat mitigation factors for fans travelling to the stadium, which can include resources such as misting stations, fans, hydration stations, cooling tents and more around the stadium footprint," Fifa's statement said.

"Inside the stadium footprint, pricing for water bottles for the Fifa World Cup 2026 will remain consistent with other events held at each stadium."

The change in policy comes amid complaints that fans are being hit by "extortionate" ticket prices and inflated train fares.

Fans were also prevented from taking bottles into stadiums at the last World Cup in Qatar.

The Free Lions England fans' group called the move a "strange, late change".

In a statement posted on X, it added: "In all of our discussions, free water availability in stadiums was a key one and we were assured by Fifa that this would be the case and that fans will have the ability to bring their own water bottle.

"Naturally, the immediate thought from supporters is this is just the latest money-grab. For how hot the stadiums will be, many in open air, just let fans bring a bottle if they want to.

"We hope the water fountains in stadiums will still be free, hopefully you aren't charged in the queue!"

Fifa have responded to heat safety concerns by introducing one three-minute hydration break in each half for every game at the tournament.

But Ollie Jay, a professor of heat and health at the University of Sydney, says he is more worried about spectator welfare than that of players.

"If you look at the athlete population, all of them are very fit," Jay said.

"Whereas if you think about the spectators, you've got a broad range of different people that will be attending, from young kids to elderly people, people with chronic diseases, people taking different types of medications – all of which results in different levels of heat sensitivity.

"Your average spectator is probably going to be less resilient to the heat than these highly-conditioned professional athletes."

He warned that heat strain could accumulate progressively as fans are exposed to heat on their journey to the game and risk arriving at the stadium in a state of dehydration.

"It's not just the temperature that we need to be concerned about," Jay added.

"If you think about your average spectator sitting in a closely confined area surrounded by lots of other people, they'll be in direct sunlight. It might be humid. The airflow might be low.

"And therefore, the amount of heat stress that their body has to cope with could be quite significant."

In May, Jay was one of 20 experts who signed an open letter to Fifa warning that guidelines left players at risk of serious harm.

Plans for misting systems and shaded areas were called "inadequate" – and Jay says that the bottle ban endangers fans further: "Unless the cooling controls are really successful, I would imagine this decision [to ban water bottles in stadiums] will clearly heighten the risk of heat-related health incidents."

Dr Theodore Keeping from Imperial College London, author of a World Weather Attribution study of heat safety at the tournament, stressed the importance of access to water.

"Allowing fair and equitable access to hydration is a basic first defence against the extreme heat risks climate change is bringing to this World Cup," Keeping said.

Andrew Simms, from the New Weather Institute, said: "Is Fifa climate-trolling the game it's meant to protect?

"It is already staging the most polluting World Cup ever, sponsored by one of the world's biggest climate-polluting oil companies, and has heat safety protocols heavily criticised by world leading health experts.

"Now making it even more difficult for fans to stay safe in a competition vulnerable to global heating seems to be a reckless rejection of Fifa's duty of care."

Everything you need to know about the World Cup

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Trump says Eiffel Tower-like UFC structure may stay on White House lawn

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Around 4,300 people are set to watch the event on the White House's South Lawn

President Donald Trump has compared the UFC structure being built at the White House to the Eiffel Tower and says he may "never, ever take it down".

The UFC is set to host an unprecedented show on the South Lawn of the home of the United States' leader in Washington DC on 14 June, to mark 250 years of American independence.

Construction has started, with workers assembling domed arches over a staging area which will become the octagon.

Trump says he may choose to leave the arena standing because it is "attractive to a lot of people", like when Paris decided to keep the Eiffel Tower.

The famous structure, built in 1889 as part of the World's Fair to celebrate 100 years of the French Revolution, was planned to be taken down 20 years later before French authorities decided to keep it.

"Many don't know that it was supposed to be taken down immediately after the World's Fair," Trump said on Tiktok.

"They said 'you know, we sort of like it, let's leave it up a little longer'. And then they said 'let's leave it longer and longer' and they never took it down.

"We're building something in front of the White House that's quite attractive to a lot of people. And I'm looking at it and maybe we'll never, ever take it down."

Watch: UFC arena construction begins at White House

The event is called UFC Freedom 250 with the UFC set to spend around $60m (£44.3m) on the project.

The show is headlined by a unification bout between Georgian-Spanish lightweight champion Ilia Topuria and American interim title holder Justin Gaethje.

In the co-main event Brazil's Alex Pereira faces Frenchman Ciryl Gane for the interim heavyweight title.

UFC president Dana White said last month that 4,300 people will watch the event on the South Lawn, most of whom will be members of the military, while 85,000 tickets will be made available for free to members of the public to watch the event at the nearby Ellipse Park.

The UFC said no tickets will be on general sale to the public.

The White House has hosted recreational sports and events in the past, but the UFC's show will mark the first professional live sporting event to take place on the grounds.

The event marks another White House construction in a series of projects by the Trump administration to remake the residence.

Since returning to the White House for a second term last year, Trump has added gold details to the Oval Office, paved over the rose garden to install a patio space, refurbished the bathroom attached to the Lincoln bedroom and demolished the East Wing to make room for a new ballroom.

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Eight and out – Gay's Test debut doesn't go to plan against New Zealand

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England's Emilio Gay falls for eight on Test debut as he's caught off the bowling of Kyle Jamieson with the home side 16-1 on the first morning of the first Test against New Zealand at Lord's.

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